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1

Synthetic probes for the α-factor receptor

Fred Naider, Arieh Yaron, Ariel Ewenson, Michael Tallon, Chu-Biao Xue, Jaya V. Srinivasan, Effimia Eriotou-Bargiota, Jeffrey M. Becker

Journal:

Year:

1990

Language:

english

File:

PDF, 818 KB

english, 1990

2

Studies on the yeast α-mating factor: A model for mammalian peptide hormones

Fred Naider, John Gounarides, Chu-Biao Xue, Effimia Bargiota, Jeffrey M. Becker

Journal:

Year:

1992

Language:

english

File:

PDF, 390 KB

english, 1992

3

ChemInform Abstract: Synthesis and Antiplatelet Effects of an Isoxazole Series of Glycoprotein IIb/IIIa Antagonists.

Chu-Biao Xue, John Roderick, Shaker Mousa, Richard E. Olson, William F. DeGrado

Journal:

Year:

1999

File:

PDF, 32 KB

1999

4

ChemInform Abstract: P1,P2′-Linked Macrocyclic Amine Derivatives as Matrix Metalloproteinase Inhibitors.

James J.-W. Duan, Lihua Chen, Chu-Biao Xue, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Robert R. Copeland, Elizabeth C. Arner, Carl P. Decicco

Journal:

Year:

1999

File:

PDF, 37 KB

1999

5

ChemInform Abstract: Asymmetric Synthesis of trans-2,3-Piperidinedicarboxylic Acid and trans-3,4-Piperidinedicarboxylic Acid Derivatives.

Chu-Biao Xue, Xiaohua He, John Roderick, Ronald L. Corbett, Carl P. Decicco

Journal:

Year:

2002

File:

PDF, 33 KB

2002

6

Rational Design, Synthesis and Structure—Activity Relationships of a Cyclic Succinate Series of TNF-α Converting Enzyme Inhibitors. Part 2. Lead Optimization.

Chu-Biao Xue, et al. et al.

Journal:

Year:

2004

File:

PDF, 70 KB

2004

7

Rational Design, Synthesis and Structure—Activity Relationships of a Cyclic Succinate Series of TNF-α Converting Enzyme Inhibitors. Part 1. Lead Identification.

Chu-Biao Xue, et al. et al.

Journal:

Year:

2004

File:

PDF, 105 KB

2004

8

Synthesis and Structure—Activity Relationship of a Novel Sulfone Series of TNF-α Converting Enzyme Inhibitors.

Chu-Biao Xue, Xiao-Tao Chen, et al. et al.

Journal:

Year:

2004

File:

PDF, 32 KB

2004

9

ChemInform Abstract: Discovery of INCB3344 (I), a Potent, Selective and Orally Bioavailable Antagonist of Human and Murine CCR2.

Chu-Biao Xue, et al. et al.

Journal:

Year:

2011

File:

PDF, 21 KB

2011

10

N-phosphoryl amino acids and peptides. Part II: Fast atom bombardment mass spectrometry of N-di-isopropyloxyphosphoryl and N-dibutyloxyphosphoryl amino acids

Chu-Biao Xue, Ying-Wu Yin, Xiao Yu, Yu-Fen Zhao

Journal:

Journal of Mass Spectrometry

Year:

1989

Language:

english

File:

PDF, 314 KB

english, 1989

11

Novel fragmentation of N-diisopropyloxyphosphoryl dipeptides and tripeptides by fast atom bombardment mass spectrometry

Yu-Fen Zhao, De-Qing Zhang, Chu-Biao Xue, Jia-Ning Zeng, Gai-Jiao Ji

Journal:

Journal of Mass Spectrometry

Year:

1991

Language:

english

File:

PDF, 283 KB

english, 1991

12

Novel synthesis of Nα-methyl-arginine and Nα-methyl-ornithine derivatives

Chu-Biao Xue, William F. DeGrado

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 270 KB

english, 1995

13

Design, synthesis and in vitro activities of a series of benzimidazole/benzoxazole glycoprotein IIb/IIIa inhibitors

Chu-Biao Xue, Maria Rafalski, John Roderick, Charles J. Eyermann, Shaker Mousa, Richard E. Olson, William F. DeGrado

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 304 KB

english, 1996

14

Potent matrix metalloproteinase inhibitors: Amino-carboxylate compounds containing modifications of the P1 residue

Chu-Biao Xue, Xiaohua He, John Roderick, William F. DeGrado, Carl Decicco, Robert A. Copeland

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1996

Language:

english

File:

PDF, 264 KB

english, 1996

15

Rational design, synthesis and structure–Activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 1: lead identification

Chu-Biao Xue, Xiaohua He, John Roderick, Ronald L. Corbett, James J.-W. Duan, Rui-Qin Liu, Maryanne B. Covington, Robert C. Newton, James M. Trzaskos, Ronald L. Magolda, Ruth R. Wexler, Carl P. Decicc

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 179 KB

english, 2003

16

Rational design, synthesis and structure–activity relationships of a cyclic succinate series of TNF-α converting enzyme inhibitors. Part 2: lead optimization

Chu-Biao Xue, Xiaohua He, John Roderick, Ronald L Corbett, James J.-W Duan, Rui-Qin Liu, Maryanne B Covington, Mingxin Qian, Maria D Ribadeneira, Krishna Vaddi, David D Christ, Robert C Newton, James

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 234 KB

english, 2003

17

Synthesis and structure–activity relationship of a novel sulfone series of TNF-α converting enzyme inhibitors

Chu-Biao Xue, Xiao-Tao Chen, Xiaohua He, John Roderick, Ronald L. Corbett, Bahman Ghavimi, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Maria D. Ribadeneira, Krishna Vaddi, James Trzaskos, Robert

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2004

Language:

english

File:

PDF, 310 KB

english, 2004

18

A new 4-(2-methylquinolin-4-ylmethyl)phenyl P1′ group for the β-amino hydroxamic acid derived TACE inhibitors

Xiao-Tao Chen, Bahman Ghavimi, Ronald L. Corbett, Chu-Biao Xue, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Krishna G. Vaddi, David D. Christ, Karl D. Hartman, Maria D. Ribadeneira, James M. Trz

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 185 KB

english, 2007

19

Hydantoins, triazolones, and imidazolones as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

James E. Sheppeck II, John L. Gilmore, Andrew Tebben, Chu-Biao Xue, Rui-Qin Liu, Carl P. Decicco, James J.-W. Duan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 530 KB

english, 2007

20

Discovery of β-benzamido hydroxamic acids as potent, selective, and orally bioavailable TACE inhibitors

James J.-W. Duan, Lihua Chen, Zhonghui Lu, Chu-Biao Xue, Rui-Qin Liu, Maryanne B. Covington, Mingxin Qian, Zelda R. Wasserman, Krishna Vaddi, David D. Christ, James M. Trzaskos, Robert C. Newton, Carl

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2008

Language:

english

File:

PDF, 268 KB

english, 2008

21

Discovery of INCB3344, a potent, selective and orally bioavailable antagonist of human and murine CCR2

Chu-Biao Xue, Anlai Wang, David Meloni, Ke Zhang, Ling Kong, Hao Feng, Joseph Glenn, Taisheng Huang, Yingxin Zhang, Ganfeng Cao, Rajan Anand, Changsheng Zheng, Michael Xia, Qi Han, D.J. Robinson, Lou

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 881 KB

english, 2010

22

Design and synthesis of novel CCR2 antagonists: Investigation of non-aryl/heteroaryl binding motifs

John I. Trujillo, Wei Huang, Robert O. Hughes, D. Joseph Rogier, Steven R. Turner, Rajesh Devraj, Philip A. Morton, Chu-Biao Xue, Ganfeng Chao, Maryanne B. Covington, Robert C. Newton, Brian Metcalf

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 1.05 MB

english, 2011

23

Studies on phosphoserine and phosphothreonine derivatives: N-diisopropyloxyphosphoryl-serine and -threonine in alcoholic media

Chu-Biao Xue, Ying-Wu Yin, Yu-Fen Zhao

Journal:

Tetrahedron Letters

Year:

1988

Language:

english

File:

PDF, 304 KB

english, 1988

24

Efficient regioselective isoprenylation of peptides in acidic aqueous solution using zinc acetate as catalyst

Chu-Biao Xue, Jeffrey M. Becker, Fred Naider

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 272 KB

english, 1992

25

Discovery of N-Hydroxy-2-(2-oxo-3-pyrrolidinyl)acetamides as potent and selective inhibitors of tumor necrosis factor-α converting enzyme (TACE)

James J.-W. Duan, Zhonghui Lu, Chu-Biao Xue, Xiaohua He, Jennifer L. Seng, John J. Roderick, Zelda R. Wasserman, Rui-Qin Liu, Maryanne B. Covington, Ronald L. Magolda, Robert C. Newton, James M. Trzas

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2003

Language:

english

File:

PDF, 253 KB

english, 2003

26

Synthesis and antiplatelet effects of an isoxazole series of glycoprotein IIb/IIIa antagonists

Chu-Biao Xue, John Roderick, Shaker Mousa, Richard E. Olson, William F. DeGrado

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1998

Language:

english

File:

PDF, 271 KB

english, 1998

27

Macrocyclic hydroxamate inhibitors of matrix metalloproteinases and TNF-α production

Robert J. Cherney, Li Wang, Dayton T. Meyer, Chu-Biao Xue, Elizabeth C. Arner, Robert A. Copeland, Maryanne B. Covington, Karl D. Hardman, Zelda R. Wasserman, Bruce D. Jaffee, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 290 KB

english, 1999

28

P1, P2′-Linked macrocyclic amine derivatives as matrix metalloproteinase inhibitors

James J.-W. Duan, Lihua Chen, Chu-Biao Xue, Zelda R. Wasserman, Karl D. Hardman, Maryanne B. Covington, Robert R. Cope, Elizabeth C. Arner, Carl P. Decicco

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 292 KB

english, 1999

29

Design, synthesis, and in vitro activities of benzamide-core glycoprotein IIb/IIIa antagonists: 2,3-Diaminopropionic acid derivatives as surrogates of aspartic acid

Chu-Biao Xue, John Roderick, Sharon Jackson, Maria Rafalski, Arlene Rockwell, Shaker Mousa, Richard E. Olson, William F. DeGrado

Journal:

Bioorganic & Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 1021 KB

english, 1997

30

Chemical synthesis of the M-factor mating pheromone from Schizosaccharomyces pombe

Shu-Hua Wang, Chu-Biao Xue, Olaf Nielsen, Dr John Davey, Fred Naider

Journal:

Year:

1994

Language:

english

File:

PDF, 567 KB

english, 1994

31

Mass spectrometric signature of S-prenylated cysteine peptides

Albert A. Tuinman, Deborah A. Thomas, Kelsey D. Cook, Chu-Biao Xue, Fred Naider, Jeffrey M. Becker

Journal:

Analytical Biochemistry

Year:

1991

Language:

english

File:

PDF, 491 KB

english, 1991

32

A new peptide coupling reagent—Dialkyl phosphite

Jia-Ning Zeng, Chu-Biao Xue, Qing-Wu Chen, Yu-Fen Zhao

Journal:

Bioorganic Chemistry

Year:

1989

Language:

english

File:

PDF, 550 KB

english, 1989

33

Discovery of novel hydantoins as selective non-hydroxamate inhibitors of tumor necrosis factor-α converting enzyme (TACE)

James E. Sheppeck II, John L. Gilmore, Anle Yang, Xiao-Tao Chen, Chu-Biao Xue, John Roderick, Rui-Qin Liu, Maryanne B. Covington, Carl P. Decicco, James J.-W. Duan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2007

Language:

english

File:

PDF, 180 KB

english, 2007

34

Identification of a Selectivity Determinant for Inhibition of Tumor Necrosis Factor-α Converting Enzyme by Comparative Modeling

Zelda R Wasserman, James J.-W Duan, Matthew E Voss, Chu-Biao Xue, Robert J Cherney, David J Nelson, Karl D Hardman, Carl P Decicco

Journal:

Chemistry & Biology

Year:

2003

Language:

english

File:

PDF, 298 KB

english, 2003

35

Aggrecanase: A Target for the Design of Inhibitors of Cartilage Degradation

ELIZABETH C. ARNER, MICHAEL A. PRATTA, CARL P. DECICCO, CHU-BIAO XUE, ROBERT C. NEWTON, JAMES M. TRZASKOS, RONALD L. MAGOLDA, MICKY D. TORTERELLA

Journal:

Annals of the New York Academy of Sciences

Year:

1999

Language:

english

File:

PDF, 1.06 MB

english, 1999

36

Discovery of INCB9471, a Potent, Selective, and Orally Bioavailable CCR5 Antagonist with Potent Anti-HIV-1 Activity

Xue, Chu-Biao, Chen, Lihua, Cao, Ganfeng, Zhang, Ke, Wang, Anlai, Meloni, David, Glenn, Joseph, Anand, Rajan, Xia, Michael, Kong, Ling

Journal:

ACS Medicinal Chemistry Letters

Year:

2010

Language:

english

File:

PDF, 1.22 MB

english, 2010

37

Discovery of an Orally Active Series of Isoxazoline Glycoprotein IIb/IIIa Antagonists

Xue, Chu-Biao, Wityak, John, Sielecki, Thais M., Pinto, Donald J., Batt, Douglas G., Cain, Gary A., Sworin, Michael, Rockwell, Arlene L., Roderick, John J., Wang, Shuaige

Journal:

Journal of Medicinal Chemistry

Year:

1997

Language:

english

File:

PDF, 789 KB

english, 1997

38

Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist

Xue, Chu-Biao, Wang, Anlai, Han, Qi, Zhang, Yingxin, Cao, Ganfeng, Feng, Hao, Huang, Taisheng, Zheng, Changsheng, Xia, Michael, Zhang, Ke

Journal:

ACS Medicinal Chemistry Letters

Year:

2011

Language:

english

File:

PDF, 420 KB

english, 2011

39

Solution phase synthesis of Saccharomyces cerevisiae a-mating factor and its analogs

CHU-BIAO XUE, ARIEL EWENSON, JEFFREY M. BECKER, FRED NAIDER

Journal:

Chemical Biology & Drug Design

Year:

1990

Language:

english

File:

PDF, 1.10 MB

english, 1990

40

A novel reagent, dialkylphosphite, for peptide synthesis

YU-FEN ZHAO, DE-QING ZHANG, CHU-BIAO XUE

Journal:

Chemical Biology & Drug Design

Year:

1991

Language:

english

File:

PDF, 430 KB

english, 1991

41

Synthesis of S-alkyl and C-terminal analogs of the Saccharomyces cerevisiae a-factor : Influence of temperature on the stability of Fmoc and OFm groups toward HF

CHU-BIAO XUE, JEFFREY M. BECKER, FRED NAIDER

Journal:

Chemical Biology & Drug Design

Year:

1991

Language:

english

File:

PDF, 912 KB

english, 1991

42

Probing the functional conformation of the tridecapeptide mating pheromone of Saccharomyces cerevisiae through study of disulfide-constrained analogs

CHU-BIAO XUE, ANGELA MCKINNEY, HUI-FEN LU, YING JIANG, JEFFREY M. BECKER, FRED NAIDER

Journal:

Chemical Biology & Drug Design

Year:

1996

Language:

english

File:

PDF, 955 KB

english, 1996

43

Design, Synthesis, and Structure−Activity Relationships of Macrocyclic Hydroxamic Acids That Inhibit Tumor Necrosis Factor α Release in Vitro and in Vivo

Xue, Chu-Biao, Voss, Matthew E., Nelson, David J., Duan, James J.-W., Cherney, Robert J., Jacobson, Irina C., He, Xiaohua, Roderick, John, Chen, Lihua, Corbett, Ronald L.

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 399 KB

english, 2001

44

Total synthesis of the lipopeptide a-mating factor ofSaccharomyces cerevisiae

Chu-Biao Xue, Guy A. Caldwell, Jeffrey M. Becker, Fred Naider

Journal:

Biochemical and Biophysical Research Communications

Year:

1989

Language:

english

File:

PDF, 332 KB

english, 1989

45

Total in vitro maturation of the Saccharomyces cerevisiae a-factor lipopeptide mating pheromone

Stevan Marcus, Guy A. Caldwell, Chu-Biao Xue, Fred Naider, Jeffrey M. Becker

Journal:

Biochemical and Biophysical Research Communications

Year:

1990

Language:

english

File:

PDF, 493 KB

english, 1990

46

The conformation of a-factor is not influenced by the S-prenylation of Cys12

John S. Gounarides, Michelle S. Broido, Chu-Biao Xue, Jeffrey M. Becker, Fred R. Naider

Journal:

Biochemical and Biophysical Research Communications

Year:

1991

Language:

english

File:

PDF, 391 KB

english, 1991

47

Pharmacological characterization of INCB3344, a small molecule antagonist of human CCR2

Niu Shin, Frédéric Baribaud, Kathy Wang, Genjie Yang, Rich Wynn, Maryanne B. Covington, Patricia Feldman, Karen B. Gallagher, Lynn M. Leffet, Yvonne Y. Lo, Anlai Wang, Chu-Biao Xue, Robert C. Newton,

Journal:

Biochemical and Biophysical Research Communications

Year:

2009

Language:

english

File:

PDF, 309 KB

english, 2009

48

Discovery of Macrocyclic Hydroxamic Acids Containing Biphenylmethyl Derivatives at P1‘, a Series of Selective TNF-α Converting Enzyme Inhibitors with Potent Cellular Activity in the Inhibition of TNF-α Release

Xue, Chu-Biao, He, Xiaohua, Corbett, Ronald L., Roderick, John, Wasserman, Zelda R., Liu, Rui-Qin, Jaffee, Bruce D., Covington, Maryanne B., Qian, Mingxin, Trzaskos, James M., Newton, Robert C., Magol

Journal:

Journal of Medicinal Chemistry

Year:

2001

Language:

english

File:

PDF, 159 KB

english, 2001

49

Asymmetric Synthesis of trans -2,3-Piperidinedicarboxylic Acid and trans -3,4-Piperidinedicarboxylic Acid Derivatives

Xue, Chu-Biao, He, Xiaohua, Roderick, John, Corbett, Ronald L., Decicco, Carl P.

Journal:

Journal of Organic Chemistry

Year:

2002

Language:

english

File:

PDF, 74 KB

english, 2002

50

An Efficient Synthesis of Glycoprotein IIb/IIIa Inhibitor DMP728. A Novel Synthesis of N.alpha.-Methylarginine-Containing Peptide

Xue, Chu-Biao, DeGrado, William F.

Journal:

Journal of Organic Chemistry

Year:

1995

Language:

english

File:

PDF, 824 KB

english, 1995